Second Legs of the 2025 Copa Sudamericana Quarterfinals: Clashes, Favorites, and Where to Watch!

The atmosphere keeps heating up — at least for one side of each matchup. The Copa Sudamericana 2025 now reaches the second legs of the quarterfinals, revealing who will advance and finish among the top four teams — and you can enjoy the action on the pitch while also placing some Sports Bets responsibly!

The four matches take place between September 23 and 25, with semifinal spots decided between Fluminense vs. Lanús, Atlético-MG vs. Bolívar, Once Caldas vs. Independiente del Valle, and Universidad de Chile vs. Alianza Lima.

Before the referees blow the whistle and the ball starts rolling, check out the details of each clash in this stage. We’ve prepared this full guide to help you plan your picks and know where to watch every game — remembering that odds change over time and the ones presented here are only for reference.

Fluminense vs. Lanús

Lanús travels to Rio de Janeiro with a narrow 1–0 advantage, earned at home in La Fortaleza in the first leg. For the return leg of the 2025 Copa Sudamericana quarterfinals, Fluminense will host at Maracanã Stadium, at 9:30 p.m. (Brazil time), this Tuesday, September 23.

The winner of this match will face whoever advances between Universidad de Chile and Alianza Lima in the semifinals.

Head-to-Head Record

The first leg of this quarterfinal marked the first official match ever played between Lanús and Fluminense.

Predictions

On Brazilian soil, Fluminense has the advantage in 1x2 odds — where 1 is the home side, x is the draw, and 2 represents the visitors. Flu stands at 1.62, compared to 6.4 for Lanús. A draw is priced at 3.45. The qualification odds, however, are quite close, with 1.96 for Tricolor das Laranjeiras and 1.81 for the Argentines.

Where to Watch

SBT (Free-to-Air TV) and Paramount+ (Streaming).

Bet on Fluminense vs. Lanús at Blaze!

Atlético-MG vs. Bolívar

Atlético-MG managed a 2–2 draw away at Estadio Hernando Siles and now brings the tie back to Belo Horizonte. The second leg will be on Wednesday, September 24, at 7:00 p.m. (Brazil time), at Arena MRV.

The winner of this clash will face either Once Caldas or Independiente del Valle in the semifinals.

Head-to-Head Record

This will be the fourth meeting between Atlético-MG and Bolívar. In the previous three, there was one win for each side and one draw. Besides last week’s 2–2 draw, they also met in the 2000 Copa Libertadores: Atlético won 1–0 at home, while Bolívar responded with a 4–0 win in La Paz.

Predictions

The away draw left Atlético-MG with a solid advantage heading into the second leg. At home, Galo is strongly favored, with odds of 1.3 for a win in 90 minutes and 1.17 for qualification. Bolívar’s chances stand at 9.8 to win the match and 4.9 to qualify. A draw in regulation is listed at 5.2.

Where to Watch

ESPN (Pay TV) and Disney+ (Streaming).

Bet on Atlético-MG vs. Bolívar at Blaze!

Once Caldas vs. Independiente del Valle

At 9:30 p.m. (Brazil time) on Wednesday, September 24, Once Caldas hosts Independiente del Valle at Estadio Palogrande in Manizales, Colombia. The first leg in Ecuador ended 2–0 for the visitors. The winner will face either Atlético-MG or Bolívar in the semifinals.

Head-to-Head Record

The first leg marked the first-ever official meeting between Once Caldas and Independiente del Valle.

Predictions

The second leg is expected to be balanced in terms of match odds: 2.8 for a Once Caldas win, 2.54 for Independiente del Valle, and 3.2 for a draw. However, the strong away win gives Once Caldas a huge advantage in the qualification odds — 1.09 compared to 6.8 for Independiente.

Where to Watch

ESPN (Pay TV) and Disney+ (Streaming).

Bet on Once Caldas vs. Independiente del Valle at Blaze!

Universidad de Chile vs. Alianza Lima

To close out the second leg of the 2025 Copa Sudamericana quarterfinals, Universidad de Chile will host Alianza Lima at the Estadio Nacional in Santiago, at 9:30 p.m. (Brazil time), on Thursday, September 25.

The tie is still wide open after a goalless draw at Alejandro Villanueva in the first leg. A winner must be decided, and that team will face either Fluminense or Lanús in the semifinals.

Head-to-Head Record

Among the quarterfinal clashes in this year’s Sudamericana, Universidad de Chile vs. Alianza Lima is the most repeated matchup, with five meetings including the first-leg draw. Their first game was over 50 years ago, in 1972, in the Copa Libertadores. Overall, the record shows two Chilean wins, one Peruvian win, and two draws.

Predictions

The odds lean toward Universidad de Chile. At the Estadio Nacional in Santiago, the Chilean side is priced at 1.81 to win in 90 minutes, compared to 4.6 for Alianza Lima and 3.4 for the draw. For qualification, the Peruvians are at 2.7, while La U has a more favorable 1.44.

Where to Watch

Paramount+ (Streaming).

Bet on Universidad de Chile vs. Alianza Lima at Blaze!

Bet on the 2025 Copa Sudamericana at Blaze!

Very soon, we’ll know the four semifinalists of the 2025 Copa Sudamericana. Rest assured, the tournament is open for betting as authorized by MESP Ordinance 125/2024 — always remembering the importance of responsible play.

Betting is entertainment, never an investment. Keep Responsible Gaming and our Sports Betting Encyclopedia as your companions for fun, always studying data, statistics, and rules to wager consciously and avoid risks. Only use amounts you can set aside for this activity, without affecting your personal or financial life.

Bet now on the 2025 Copa Sudamericana at Blaze and celebrate the continent’s great teams!