2025 Copa Sudamericana Round of 16: Matchups, Favorites, and Where to Watch!
Get ready, because we’ve reached that stage where the Copa Sudamericana really heats up!
After thrilling Playoffs, the 2025 Copa Sudamericana Round of 16 is here! Electrifying clashes between giants, surprises, and plenty of drama await — and you can make it even more exciting with Sports Betting!
There’s a classic between neighbors, rivalry-packed reunions, and Brazilian teams looking to maintain continental dominance. And of course, with so much action on the pitch, there are plenty of opportunities for those who love following every play — and maybe having a little extra fun!
Now it’s time to break down who plays who, who’s coming in as the favorite, and where to watch each big Round of 16 match. Let’s go!
Once Caldas vs Huracán
In the opening match of the 2025 Copa Sudamericana Round of 16, Once Caldas and Huracán will face off this Tuesday (12th) at 7:00 PM at Estadio Palogrande in Manizales. This first-leg clash promises balance and high intensity, bringing together two teams riding strong momentum after solid performances in the previous stage.
Once Caldas, led by Hernán Darío Herrera, comes in with confidence after crushing San Antonio Bulo Bulo in the previous round with a 7-0 aggregate (3-0 away and 4-0 at home). Before that, the team had already shown strength by overcoming rivals like Unión Española and GV San José.
On the other side, Frank Darío Kudelka’s Huracán is also in good form. The Argentinians beat Corinthians 1-0 in the previous round, having already eliminated Racing de Montevideo and América de Cali earlier in the tournament.
Head-to-Head Record
If there’s one thing you can’t say about Once Caldas vs Huracán, it’s that there’s a history full of rivalry… because there’s no history at all! This will be the first official meeting between the two teams.
Predictions
According to the odds, the Colombian side has a slight edge to win in regulation (2.6 vs Huracán’s 3.2), but nothing to declare victory just yet, especially with the draw at 2.75, showing that parity is very possible.
When it comes to advancing to the next stage, the picture changes: Huracán is favored at 1.59 vs 2.35 for Once Caldas.
Where to Watch
The match will be broadcast on ESPN 4 and Disney+.
Bet on Once Caldas vs Huracán at Blaze!
Independiente del Valle vs Mushuc Runa
On Tuesday night (12th) at 9:30 PM (Brasília time), Estadio Banco de Guayaquil will host the first-leg clash between Independiente del Valle and Mushuc Runa. This game pits one of the tournament’s most traditional clubs against one of the biggest surprises of the season.
Independiente del Valle, coached by Javier Rabanal, reached the Sudamericana after competing in the Copa Libertadores group stage and made an immediate statement, eliminating Vasco da Gama with authority: 4-0 at home and a 1-1 draw in Rio de Janeiro.
On the other side, Mushuc Runa, now led by Paúl Vélez, is one of the unexpected highlights of this edition. After a strong group stage, they left behind opponents like Cruzeiro, Unión de Santa Fe, and Palestino, proving they can surprise even without the same resources as the bigger clubs.
Head-to-Head Record
The teams have met 27 times in total, with Independiente dominating the series: 20 wins, only four losses, and three draws. At Estadio Banco de Guayaquil, the advantage is even more striking: in 14 matches, the home side has won 11, drawn one, and lost just twice. Even at Mushuc Runa’s home, things don’t change much: nine wins for Independiente, two draws, and only two losses in 13 games.
Predictions
In regulation, Del Valle is the heavy favorite (1.38), while Mushuc Runa is considered the underdog with odds of 7.8. The draw sits in the middle at 4.9.
For qualification, the favoritism is even clearer: 1.26 for Del Valle to advance vs 3.8 for Mushuc Runa.
Where to Watch
The match will be broadcast on ESPN and Disney+.
Bet on Independiente del Valle vs Mushuc Runa here at Blaze!
América de Cali vs Fluminense
On Tuesday (12th) at 9:30 PM (Brasília time), Estadio Olímpico Pascual Guerrero in Cali will host the first-leg match between América de Cali and Fluminense.
América de Cali, coached by Gabriel Raimondi, comes in strong after eliminating Bahia in the playoffs. They had two solid performances — a goalless draw in Salvador and a 2-0 home win. In the group stage, they maintained consistency against opponents like Corinthians, Huracán, and Racing (Montevideo).
On the other side, Renato Gaúcho’s Fluminense has had an impressive campaign. In the group stage, they overcame teams like Once Caldas, Unión Española, and GV San José, advancing with authority and strong performances.
Head-to-Head Record
There’s no past between these two — that’s right, this will be their first official meeting.
Predictions
For the first leg, the odds are extremely balanced: América win (2.7) vs Flu win (2.75), with the draw at 3.05. But for qualification, the tide turns: Fluminense is favored at 1.45, while América de Cali sits at 2.7.
Where to Watch
The match will be broadcast on SBT and Paramount+.
Bet on América de Cali vs Fluminense at Blaze!
Bolívar vs Cienciano
On Wednesday (13th) at 7:00 PM, Estadio Hernando Siles in La Paz will host the first leg between Bolívar and Cienciano in a clash that promises emotion and a fierce battle in the Bolivian altitude.
Bolívar, under Flavio Robatto, arrives after a challenging Copa Libertadores campaign, facing giants like Palmeiras and Cerro Porteño. Dropping into the Sudamericana after the group stage, they come in motivated, having already beaten Palestino 6-0 on aggregate.
On the other side, Cienciano, coached by Carlos Desio, has been a solid and surprising side in this Sudamericana. After advancing past teams like Deportes Iquique, Caracas FC, and Atlético Mineiro, the Peruvian team has shown balance and picked up good results both at home and away, remaining unbeaten in the tournament.
Head-to-Head Record
The history between Bolívar and Cienciano is short, and all the bragging rights belong to the Peruvians — in just two official matches, Cienciano won both.
Predictions
Bolívar is the big favorite with odds of 1.5. The draw (4.7) seems less likely, and a Cienciano win (6.0) is considered a long shot.
Where to Watch
The match will be broadcast on Paramount+.
Bet on Bolívar vs Cienciano at Blaze!
Universidad de Chile vs Independiente
On Wednesday (13th) at 9:30 PM, Estadio Nacional in Santiago will host the first leg between Universidad de Chile and Independiente in a clash that promises to be intense, with two traditional clubs fighting for a spot in the quarterfinals with grit and skill.
Universidad de Chile, coached by Gustavo Álvarez, comes into the match motivated after their Libertadores group stage campaign. Following their elimination, they crushed Guarani 6-2 on aggregate in the Sudamericana and will look to capitalize on home advantage.
On the other side, Julio Vaccari’s Independiente boasts a dominant record in the tournament, including routs like a 7-0 win over Nacional Potosí. With a sharp attack and offensive style, the Argentine team won’t make things easy.
Head-to-Head Record
The two sides have met only twice, with each winning once — the head-to-head is completely even.
Predictions
The odds are close: Universidad de Chile win at 2.75, draw at 3.05, and Independiente win at 2.8. This game promises balance from start to finish.
Where to Watch
The match will be broadcast on ESPN and Disney+.
Bet on Universidad de Chile vs Independiente at Blaze!
Alianza Lima vs Universidad Católica
On Wednesday (13th) at 9:30 PM, Estadio Alejandro Villanueva in Lima will host the first leg between Alianza Lima and Universidad Católica.
Alianza Lima, coached by Néstor Gorosito, arrives after being eliminated in the Copa Libertadores group stage, and after eliminating Grêmio convincingly in the Sudamericana with a 3-1 aggregate win.
On the other side, Universidad Católica, led by Diego Martínez, has shown great consistency in the Sudamericana, with important wins and strong results against tough opponents like Vitória, Cerro Largo, and Defensa y Justicia. The Ecuadorian side comes in confident looking to get a good away result.
Head-to-Head Record
They have met only twice: Universidad Católica has one win and there’s been one draw. Interestingly, Católica won when playing in Alianza’s home, but when playing at home, they could only manage a draw.
Predictions
Alianza Lima is the clear favorite with odds of 1.75. The draw is further out at 3.6, and Universidad Católica is the underdog at 5.0.
Where to Watch
The match will be broadcast on Paramount+.
Bet on Alianza Lima vs Universidad Católica at Blaze!
Atlético Mineiro vs Godoy Cruz
On Thursday (14th) at 7:00 PM, Arena MRV in Belo Horizonte will host the first leg between Atlético Mineiro and Godoy Cruz.
Atlético Mineiro, coached by Cuca, comes into the match boosted after eliminating Bucaramanga on penalties in a dramatic battle that showcased the team’s strength and grit. With strong recent performances and home advantage, the Galo will look to control the match and build a solid lead for the return leg.
On the other side, Godoy Cruz, who appointed Walter Ribonetto as head coach just last weekend, has been competitive in the Sudamericana, with solid results including draws against Grêmio and important away wins — despite being in the relegation zone in the national league.
Head-to-Head Record
Looking at past encounters, Atlético Mineiro holds a slight edge: two games, with one win for Galo and one draw. At home, Atlético has a 100% record from their single match against Godoy Cruz, while in Argentina, the match ended in a draw.
Predictions
Atlético Mineiro is the clear favorite with odds of 1.52. The draw at 3.9 is a reasonable possibility if the match is tight. Godoy Cruz has odds of 7.25 and will need to capitalize on any slip-ups to pull off a surprise.
Where to Watch
The match will be broadcast on ESPN and Disney+.
Bet on Atlético Mineiro vs Godoy Cruz at Blaze!
Central Córdoba vs Lanús
On Thursday (14th), Estadio Único Madre de Ciudades in Santiago del Estero will host the first leg between Central Córdoba and Lanús. Kickoff is at 9:30 PM, promising the unique flavor of an all-Argentine clash.
Central Córdoba arrives in good spirits after knocking out Cerro Largo without conceding a goal in either match, winning 3-0 in the return leg. Before that, coach Omar De Felippe’s team had competed in the Libertadores, pulling off historic wins like the one against Flamengo at Maracanã, though they ultimately fell short in the group stage.
On the other side, Mauricio Pellegrino’s Lanús had a strong Sudamericana group stage campaign, going unbeaten and earning key wins like 3-0 over Melgar and 1-0 over Vasco. The Granate showed balance, with a solid defense and an attack that makes the most of its chances.
Head-to-Head Record
This is a fixture that loves balance: in nine meetings, both teams have won twice, with no fewer than five draws.
When playing at Lanús’ home, the Granate has a slight advantage: two wins, one draw, and one loss. In Santiago del Estero, there have been five matches — four draws and one win for the home side.
Predictions
This promises to be a tightly contested game, and the odds back that up! Central Córdoba has a slight edge at 2.55 to win. The draw is at 2.95, and a Lanús win is at 3.15 — a bit higher, but still very possible.
Where to Watch
The match will be broadcast on Paramount+.
Bet on Central Córdoba vs Lanús at Blaze!
Bet on the 2025 Copa Sudamericana at Blaze!
The knockout stage is here, and from now on, the excitement for the 2025 Copa Sudamericana Round of 16 only grows! Just as teams need to play responsibly to advance, you should also approach your betting with care.
Don’t risk too much of your finances! Only bet amounts you’ve set aside for fun, always remembering that betting is entertainment, not investment!
Now that you know what to expect from this round, you can place your bets on the 2025 Sudamericana Round of 16 here at Blaze. Let’s enjoy this stage with responsibility and even more excitement!