Second Leg of the 2025 Copa Sudamericana Playoffs: Matchups, Favorites, and Where to Watch!
Fans are about to find out who will advance to the Round of 16 of the 2025 Copa Sudamericana!
Between Tuesday (22) and Thursday (24), the second legs of the 2025 Copa Sudamericana playoffs will be played. Fans will finally discover which teams will make it to the Round of 16 — and have more chances to boost the excitement of the matches with sports betting.
This stage features the second-place teams from each Sudamericana group and the third-place teams from the Copa Libertadores groups. There are eight clashes, and you can check out the favorites and broadcast info in this special guide prepared by Blaze!
Cerro Largo vs Central Córdoba
The scoreboard remains untouched in the Cerro Largo vs Central Córdoba duel. The first leg ended in a goalless draw in Argentina. Now, both teams meet again this Tuesday (22), at 7 PM (Brasília time), at the Campeón del Siglo stadium.
Head-to-Head Record
The first leg was the only meeting between the two teams so far.
Predictions
Even though Cerro Largo plays at home, their odds aren't as favorable as Central Córdoba’s: 3.45 for the hosts and 2.21 for the visitors, with a 3.15 draw. Since the first leg ended 0-0, the Argentinians have the edge in qualification odds: 1.65 vs 2.24 for the Uruguayans.
Where to Watch
ESPN (cable TV) and Disney+ (streaming).
Bet on Cerro Largo vs Central Córdoba at Blaze!
América de Cali vs Bahia
Another 0-0 draw marked the first leg between Bahia and América de Cali at Fonte Nova. So, the team that actually advances to the Round of 16 will be decided at Pascual Guerrero Stadium. This match is also on Tuesday (22), but at 9:30 PM (Brasília time).
Head-to-Head Record
The first leg was the first-ever meeting between América de Cali and Bahia.
Predictions
This is shaping up to be the most balanced match of the Sudamericana playoff round. In 1x2 odds (1 = home team, x = draw, 2 = away team), América de Cali is at 2.55, the draw at 3.15, and Bahia close behind at 2.85. Qualification odds are even tighter: 1.84 for the Colombians and 1.97 for the Brazilians.
Where to Watch
ESPN (cable TV) and Disney+ (streaming).
Bet on América de Cali vs Bahia at Blaze!
Vasco vs Independiente del Valle
Vasco’s situation is tough. The Rio team suffered a painful 4-0 defeat in the first leg against Independiente del Valle. Now, the team must try to overturn the result at São Januário. The match takes place simultaneously with the one above, at 9:30 PM (Brasília time), on Tuesday (22).
Head-to-Head Record
Vasco and Independiente del Valle have only faced each other once — during the first leg of these playoffs.
Predictions
Despite playing at home, the massive deficit from the first leg makes Vasco's qualification extremely difficult. They are favored to win the match at 1.84 odds, but their qualification odds sit at a distant 14.0. Meanwhile, the Ecuadorians are less likely to win the match (4.3 odds) but almost guaranteed to go through (1.01 odds).
Where to Watch
SBT (free-to-air TV).
Bet on Vasco vs Independiente del Valle at Blaze!
Palestino vs Bolívar
Another big win happened in the first leg between Bolívar and Palestino. The Bolivians won 3-0 at home. Now at the National Stadium in Santiago, Palestino must prove their strength to stay in the tournament. This match opens Wednesday’s action (23), at 7 PM (Brasília time).
Head-to-Head Record
The teams have faced each other three times, with Bolívar winning all three. Besides the first leg of this playoff, they also met in Group E of the 2024 Libertadores.
Predictions
Here, the home team is favored to win the 90 minutes but is unlikely to qualify. Palestino has 1.81 odds to win, compared to Bolívar’s 4.1 and 3.85 for a draw. However, when it comes to qualification, Bolívar is heavily favored (1.08) over Palestino (7.6).
Where to Watch
ESPN (cable TV) and Disney+ (streaming).
Bet on Palestino vs Bolívar at Blaze!
Grêmio vs Alianza Lima
Grêmio also lost the first leg, but with a more manageable scoreline. Alianza Lima won 2-0 at home. Now, the Tricolor Gaúcho needs at least a draw to take the game to penalties in the second leg, which takes place Wednesday (23) at 9:30 PM (Brasília time), at Arena do Grêmio, to stay alive in the Sudamericana.
Head-to-Head Record
Grêmio and Alianza Lima have known each other for nearly 30 years. Their first meeting was in the 1997 Libertadores, when the Brazilian side won both matches. Now, the record includes the recent Peruvian victory.
Predictions
Grêmio will do everything to turn things around, and the odds reflect a possible win for the hosts: 1.57 in the 1x2 market, compared to 5.4 for Alianza Lima and 4.2 for a draw. However, when it comes to qualification, the Peruvians are favored at 1.35, versus 3.2 for Grêmio.
Where to Watch
Paramount+ (streaming).
Bet on Grêmio vs Alianza Lima at Blaze!
Once Caldas vs San Antonio Bulo Bulo
Once Caldas thrashed San Antonio Bulo Bulo — debutants in the Libertadores and still hanging on in the Sudamericana — in the first leg with a 3-0 victory. At home in Estadio Palogrande, the Bolivians will need a big win to overturn the deficit. Kickoff is also scheduled for 9:30 PM (Brasília time), on Wednesday (23).
Head-to-Head Record
The first leg was the only meeting between the two teams so far.
Predictions
Once Caldas made things much easier for themselves with the 3-0 win, significantly increasing their chances of reaching the Round of 16 in the 2025 Copa Sudamericana. In the 1x2 odds, the home side is heavily favored at 1.27, while San Antonio Bulo Bulo sits at 11.0. The draw stands at 5.6.
Where to Watch
Paramount+ (streaming).
Bet on Once Caldas vs San Antonio Bulo Bulo at Blaze!
Guaraní vs Universidad de Chile
Among the many blowouts in the first legs of the Sudamericana 2025 playoffs, one stood out the most: Universidad de Chile defeated Guaraní 5-0. Now, at Defensores del Chaco in Asunción, Paraguay, there will be 90 minutes of drama and a chase for a miracle. This match opens Thursday’s (24) fixtures at 7:00 PM (Brasília time).
Head-to-Head Record
The first meeting was in the 1966 Copa Libertadores. Since then, the teams have faced each other seven times: Universidad de Chile won four, Guaraní one, and two matches ended in draws.
Predictions
Despite the 5-0 result in the first leg, the return leg could be more balanced. In the 90-minute match odds (not qualification), Guaraní is at 2.49, followed closely by Universidad de Chile at 2.9. The draw is also in play at 3.25.
Where to Watch
Paramount+ (streaming).
Bet on Guaraní vs Universidad de Chile at Blaze!
Atlético-MG vs Atlético Bucaramanga
The Brazilian team in the most comfortable position is Atlético-MG. The club won by a narrow 1-0 margin away from home in the first leg of the playoffs against Atlético Bucaramanga. The Galo will host the Colombians at Arena MRV on Thursday (24) at 9:30 PM (Brasília time).
Head-to-Head Record
These teams have only played once in history — the first leg of this playoff series.
Predictions
Atlético-MG is heavily favored to advance in the continental competition, with odds of 1.04 compared to 11.0 for the Colombians. In terms of winning the 90-minute match, the Brazilian side leads at 1.33, while Atlético Bucaramanga sits at 9.2. The draw is listed at 5.2.
Where to Watch
ESPN (cable TV) and Disney+ (streaming).