2025 Copa Sudamericana Draw: CONMEBOL Defines Round of 16 Matchups and Full Bracket!

After an exciting Group Stage, it’s time to narrow the field even further in South America’s second-most prestigious continental tournament. The 2025 Copa Sudamericana draw was held this Monday (June 2) in Luque, Paraguay, and now every club knows its route to the final on November 22 — and sports betting fans can also start planning.

Universidad de Chile, Lanús, Independiente, Cienciano, and Independiente del Valle are the only five remaining teams that have previously lifted the Sudamericana trophy. Among the early favorites, Cruzeiro and Corinthians were eliminated — opening the door for surprises like Mushuc Runa, who topped Group E and remain unbeaten.

Below, you’ll find all the Playoff matchups, which will take place shortly after the FIFA Club World Cup. And of course, we’ll show who faces who in the Round of 16, Quarter-Finals, and Semi-Finals of the 2025 Copa Sudamericana:

What Are the 2025 Copa Sudamericana Playoff Matches?

With eight spots in the Round of 16 still up for grabs, the Playoff round will feature the group stage runners-up facing the teams that dropped down from the Libertadores — including Bahia, the only one among four Brazilian clubs entering from that competition.

Check out the eight matchups scheduled for the second half of July:

• A: Alianza Lima vs Grêmio
• B: San Antonio Bulo Bulo vs Once Caldas
• C: Atlético Bucaramanga vs Atlético-MG
• D: Bolívar vs Palestino
• E: Bahia vs América de Cali
• F: Independiente del Valle vs Vasco
• G: Universidad de Chile vs Guaraní
• H: Central Córdoba vs Cerro Largo

What Are the Round of 16 Matches of the 2025 Copa Sudamericana?

Once the Playoff stage is settled, the winners will face the group stage winners between August 12 and 14. The return legs will be played between August 19 and 21.

Here are the Round of 16 matchups for the 2025 Copa Sudamericana:

• 1: Winner of Playoff A vs Universidad Católica
• 2: Winner of Playoff B vs Cienciano
• 3: Winner of Playoff C vs Huracán
• 4: Winner of Playoff D vs Fluminense
• 5: Winner of Playoff E vs Lanús
• 6: Winner of Playoff F vs Mushuc Runa
• 7: Winner of Playoff G vs Godoy Cruz
• 8: Winner of Playoff H vs Independiente

Full Knockout Bracket for the 2025 Copa Sudamericana

If you’re looking to plan your bets — or even a trip to watch the grand final on November 22 in Santa Cruz de la Sierra, Bolivia — here’s how the path unfolds.

The Quarter-Finals will take place between September 16 and 25, with the winners of Round of 16 matches 1 and 8 facing each other. Whoever advances to the Semi-Finals will take on the winner of matches 4 and 5.

On the other side of the bracket, the winners of matches 2 and 7 will face off for a spot in the Semi-Finals against whoever advances from the 6 vs 3 matchup. The Semi-Finals will be played between October 21 and 30, leaving one month to prepare for the final.

Bet on the 2025 Copa Sudamericana at Blaze!

There’s still plenty of time before the Playoff round kicks off, which means lots of data and results will be available for analysis. Just remember — football is full of surprises, and nothing is guaranteed when it comes to betting.

Also, betting is not an investment or a source of income. It should be seen purely as entertainment — and betting on a match definitely makes every play more exciting.

Deal? Bet on the 2025 Copa Sudamericana at Blaze and good luck!